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But I could say that whenever the function of the single gene is definitely knocked down, the pet can extend its lifespan. Their analysis, published in the journal Science in December 2000, says the mutations may create a metabolic declare that mimics caloric restriction, which has been shown to extend lifespan. When you look at the protein coded by this gene you can do you know what the gene will because transporters have certain structural features and the protein made by this gene has the same sort of structural features of the transportation program, Dr. Ganapathy says.