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This must be investigated in long term studies. McComsey. ‘This suggests an impact of HIV an infection itself and not antiretroviral therapy on REE. The exact mechanism where this occurs is unknown, but could be because of heightened swelling or immune activation, which takes place in HIV infection.’ Dr. McComsey also notes the necessity for further study of ART initiation to measure the effect of HIV infection on REE and the effect of specific antiretrovirals on REE.. Antiretroviral therapy does not affect resting energy expenditure in HIV-infected women Studies show that about 10 % of men infected with human being immunodeficiency virus have an increased resting energy expenditure .